Hematopoiesis: A Human Perspective

PERSPECTIVE Cancer Genes and Hematopoiesis

B LOOD CELLS and their progenitors have been the proving ground for many ideas about development and differentiation, growth factors and receptors, transcriptional control, and normal and cancerous growth.’ Because leukemias, both human and experimental, are especially accessible cancers, they have provided many of the cancer genes and oncogenic mechanisms that we know the most about.’ An abidi...

Description of the human races: A historical perspective

Human dimensions from Quranic perspective

Ever since the creation of mankind, there have been different and variable viewpoints about the aspects of the human being. Words such as "Body", "Psyche", "Soul" and "Spirit" have usually been employed regarding human by philosophers, religious scholars, physicians, psychiatrists, and psychologists. Hippocrates, Plato, Aristotle, Galen, Rhazes, Avicenna, Engle, and World Health Organization ha...

Embryonic origin of human hematopoiesis.

Hematopoietic stem cells (HSC) are at the origin of the adult hematopoietic system. They give rise to all blood cells through a complex series of proliferation and differentiation events that occur throughout the lifespan of the individual. Because of their potential clinical importance in transplantation, recent research has focused on the developmental origins of embryonic HSC. During develop...

Visualizing human ESC-derived hematopoiesis.

In this issue of Blood, Rafii et al present an elegant study of human embryonic stem cell (ESC)–derived hematopoiesis incorporating live imaging at the single-cell level to track hematopoietic lineage potential during the endothelial to hematopoietic transition.